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MRCPUK SEND Exam Syllabus Topics:
| Section | Objectives |
|---|---|
| Reproductive Endocrinology | - Hypogonadism and infertility - Polycystic ovary syndrome (PCOS) |
| Neuroendocrine Tumours and Multiple Endocrine Neoplasia | - MEN syndromes - Carcinoid and pancreatic NETs |
| Pituitary and Hypothalamic Disorders | - Diabetes insipidus and SIADH - Pituitary adenomas and hypopituitarism |
| Adrenal Disorders | - Addison disease and adrenal insufficiency - Cushing syndrome |
| Endocrine Emergencies | - Diabetic ketoacidosis and hyperosmolar states - Thyroid and adrenal crisis |
| Thyroid Disease | - Thyroid nodules and cancer - Hyperthyroidism and hypothyroidism |
| Metabolic Disorders | - Obesity management - Lipid disorders |
| Calcium, Bone and Metabolic Disease | - Osteoporosis and metabolic bone disease - Calcium and vitamin D disorders |
| Diabetes Mellitus | - Type 1 and Type 2 diabetes management - Diabetic complications and emergencies |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 25-year-old woman with type 1 diabetes mellitus presented with light-headedness, nausea, thirst and vomiting of 3 days' duration. She was fully conscious.
On examination, her pulse was 104 beats per minute and her blood pressure was 104/64 mmHg. Urinalysis showed glucose 2+, ketones 3+.
Investigations:
serum sodium150 mmol/L (137-144)
serum potassium5.5 mmol/L (3.5-4.9)
serum chloride105 mmol/L (95-107)
serum urea5.0 mmol/L (2.5-7.0)
serum creatinine90 umol/L (60-110)
random plasma glucose20.0 mmol/L
arterial blood gases, breathing air:
PO212.4 kPa (11.3-12.6)
PCO23.4 kPa (4.7-6.0)
pH7.15 (7.35-7.45)
H+70 nmol/L (35-45)
bicarbonate6 mmol/L (21-29)
What intravenous fluid should be given over the first 30 minutes?
A) sodium chloride 0.18% and glucose 4%
B) compound sodium lactate
C) sodium chloride 0.45%
D) colloid solution
E) sodium chloride 0.9%
2. A 24-year-old woman was referred with an 18-month history of worsening hirsutism, primarily on her face, but also new hair growth on her chest. She was shaving weekly. She had always been overweight, but had recently gained 5 kg and her body mass index was 31 kg/m2 (18-25). Her periods were regular.
What is the most relevant next investigation?
A) plasma thyroid-stimulating hormone
B) serum testosterone
C) serum dehydroepiandrosterone
D) serum 17-hydroxyprogesterone
E) overnight dexamethasone suppression test (after 1 mg dexamethasone)
3. A 60-year-old man with type 2 diabetes mellitus attended for an elective laparoscopic cholecystectomy. His oral hypoglycaemic medication regimen was metformin 1 g twice daily and gliclazide 160 mg twice daily. His haemoglobin A1c concentration had been 69 mmol/mol (20-42) when checked 2 months previously.
He was admitted on the morning of surgery and was on the morning list. He had fasted from midnight and taken metformin 1 g at 05.00 h.
On examination, he weighed 82 kg.
Investigations (on admission):
serum creatinine64 umol/L (60-110)
fasting plasma glucose18.1 mmol/L (3.0-6.0)
capillary blood ketones0.2 mmol/L (<1)
According to the Joint British Diabetes Societies guideline 'Management of adults with diabetes undergoing surgery and elective procedures', what is the most appropriate next step in management to bring his preoperative glucose into the acceptable range (4.0-12.0 mmol/L)?
A) variable-rate insulin infusion
B) rapid-acting analogue insulin 8 units subcutaneously
C) rapid-acting analogue insulin 16 units subcutaneously
D) cancel surgery and refer to local diabetes team
E) gliclazide 160 mg orally
4. A 64-year-old man, who was undergoing investigation for altered bowel habit, was referred to the endocrine clinic after a CT scan of abdomen had shown a 4-cm mass in his left adrenal gland. He had a history of hypertension and type 2 diabetes mellitus.
Investigations:
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol350 nmol/L (<50)
24-h urinary free cortisol400 nmol (55-250)
plasma adrenocorticotropic hormone (09.00 h)2.0 pmol/L (3.3-15.4)
He underwent laparoscopic removal of his left adrenal gland.
How should his endocrine condition be managed following surgery?
A) immediate postoperative tetracosactide (Synacthen@) test and, if abnormal, start hydrocortisone
B) 24-h urinary cortisol 6 weeks postoperatively and start hydrocortisone if abnormally low
C) start hydrocortisone perioperatively and continue until tetracosactide (Synacthen@) test in 6 weeks
D) tetracosactide (Synacthen@) test 6 weeks postoperatively and start hydrocortisone if abnormal
E) introduce hydrocortisone and fludrocortisone postoperatively according to blood pressure and electrolytes
5. A 20-year-old man presented with a 6-month history of lethargy and weakness. His brother had been found to have adrenal failure at the age of 18. He had two sisters who were well and there was no other family history of endocrine autoimmune disease.
On examination, his blood pressure was 100/60 mmHg.
Investigations:
serum sodium136 mmol/L (137-144)
serum potassium4.8 mmol/L (3.5-4.9)
short tetracosactide (Synacthen@) test (250 micrograms):
baseline serum cortisol100 nmol/L
serum cortisol (30 min after tetracosactide)250 nmol/L (>550)
anti-adrenal antibodiesnegative
What is the most important diagnosis to consider?
A) tuberculosis
B) adrenoleucodystrophy
C) autoimmune hypoadrenalism
D) familial glucocorticoid resistance
E) isolated adrenocorticotropic hormone deficiency
Solutions:
| Question # 1 Answer: E | Question # 2 Answer: B | Question # 3 Answer: B | Question # 4 Answer: C | Question # 5 Answer: B |
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